Clippers Disease
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids clippers is a central nervous system cns inflammatory disease defined in 2010 by pittock and colleagues.
Clippers disease. Long term outcomes of clippers chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids in a consecutive series of 12 patients. Many patients with clippers like lesions have been described in the literature with follow up revealing a. Therapeutic approaches in clippers.
Clippers predominantly affects the cerebellum spinal cord and brainstem the part of the brain. Taieb g duflos c renard d et al. This is a page to share information and experiences about clippers if your a sufferer or know someone who is suffering of not sure what is happening to you.
Neuropathological examination of affected regions shows a perivascular. It has a predilection for the pons with fairly characteristic curvilinear regions of enhancement best seen on mri. Clippers syndrome is a rare disorder and has only recently been described as a new disease entity in 2010 current literature only reports a few cases which raise the question of whether this really is a truly new disease or if it has simply been misdiagnosed for several years as an atypical presentation of known clinically and radiologically similar conditions such as ms.
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids clippers is a treatable inflammatory disease of the central nervous system specifically it is a type of encephalomyelitis which is a general term describing inflammation of the brain and spinal cord. Lesions may extend into the basal ganglia or the cervico thoracal medulla. Atopic disease and in particular atopic myelitis 14 15 pathological conditions presenting with elevated ige levels in response to various environmental antigens may offer clues to the link of elevated ige and distinct forms of neuroinflammatory diseases such as clippers 11.
Taieb g allou t labauge p. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids clippers is a recently defined inflammatory central nervous system cns disorder prominently involving the brainstem and in particular the pons. Clippers is a relapsing subacute brainstem syndrome presenting with symptoms such as ataxia diplopia dysarthria and altered facial sensation.
Curr treat options neurol 2017. The condition features a combination of clinical symptoms. The diagnosis of clippers is challenging without a specific biomarker and thus it is important to consider if both the clinical and radiographic features are consistent with the diagnosis or rather a disease mimicker.
